The general virus replication cycle can be divided into the following stages:
1. Attachment - a specific binding between viral surface proteins and their receptors on the host cellular surface. This specificity determines the host range of a virus.
2. Penetration - After attachment, viruses may enter the host cell through receptor mediated endocytosis, clathrin endocytosis or other mechanisms.
3. Uncoating - a process that viral capsid is degraded by viral enzymes or host enzymes.
4. Replication - involves assembly of viral proteins and genetic materials produced in the host cell.
5. Assembly - capsid is assembled around the genome.
6. Release - Viruses may escape from the host cell by causing cell rupture (lysis). Enveloped viruses (e.g., HIV) typically "bud" from the host cell. During the budding process, a virus acquires the phospholipid envelope containing the embedded viral glycoproteins.
* CLICK HERE!! If you want to have a better understanding on the cycle!! An animation have been found specially for YOU(:
Definitions
1. Receptor mediated endocytosis is an endocytotic mechanism in which specific molecules are ingested into the cell. The specificity results from a receptor-ligand interaction. Receptors on the plasma membrane of the target tissue will specifically bind to ligands on the outside of the cell. An endocytotic process occurs and the ligand is ingested.
2. Clathrin-mediated endocytosis is a vesicular transport event involved in the internalization and recycling of receptors participating in signal transduction events and nutrient import as well as in the reformation of synaptic vesicles.
No comments:
Post a Comment